Alcohol Misuse and Kidney Injury: Epidemiological Evidence and Potential Mechanisms PMC

Alcohol Misuse and Kidney Injury: Epidemiological Evidence and Potential Mechanisms PMC

alcohol and kidneys

Kidneys that have been overworked due to excess alcohol consumption don’t function properly. This makes them less able to filter blood and maintain the correct water balance in the body. The hormones that control kidney function can also be adversely affected. More than two drinks a day can increase your chance of having high blood pressure. Based on the most recent scientific evidence, if you stick to one standard alcohol drink each day (one 1.5-oz shot, one 12-oz. glass of beer or one 5-oz. glass of wine), you do not increase your risk of developing kidney disease. Also, alcohol does not appear to make kidney disease worse or make it more likely that someone with kidney disease will need dialysis.

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It also might be due to an anatomical issue, like a ureteropelvic junction obstruction. Both conditions would need to be evaluated and treated by your doctor. Heavy drinking can also cause liver disease, which also makes your kidneys work harder.

  • Figure 1 showed the crude follow up condition of the three drinking groups.
  • Chronic or acute heart failure can lead to chronic or acute dysfunction in the kidneys, known as cardiorenal syndrome (Cleland et al. 2012).
  • Kidney pain after drinking alcohol may occur due to acute kidney injury or an infection.
  • This might mean eating a healthy diet, staying hydrated, exercising, quitting smoking, and limiting alcohol consumption.
  • For example, in an early study on dogs (Chaikoff et al. 1948), investigators observed several striking alterations after chronic alcohol administration.

Does Alcohol Affect Your Kidneys?

alcohol and kidneys

In some cases, a renal vitamin or multivitamin may be recommended to you by your dietitian. Be sure to discuss with your healthcare team which type of vitamin and dose is best for you. Too much alcohol can result in high losses of magnesium in the urine.

Fast Foods that are Okay for Kidney Disease

alcohol and kidneys

This is especially likely if your liver is impaired due to alcoholism. The disease can also affect blood flow to the kidneys and cause them to be less effective in filtering blood. Drinking alcohol can affect many parts of your body, including your kidneys.

Blood-Flow Changes

This review focused on 21 clinical studies of the relationship between alcohol consumption and CKD, including 13 cohort studies and 8 cross-sectional studies. The characteristics of the study design and other details of these studies are presented in Table 1. NO is a free gaseous signal molecule produced by the NOS family, including neuronal NO synthase (nNOS), inducible NO synthase (iNOS), and endothelial NO synthase (eNOS), and it plays an important role in hemodynamics regulation. In general, NO is generated by mesangial cells and renal tubular epithelial cells, and it plays an important role in the regulation of glomerular and medullar hemodynamics and renin release. Although different studies have shown opposite results for the effects of NO and NOS activity with alcohol consumption [19,39,46,47], they came to a similar conclusion that NO and NOS play important roles in glomerular endothelial cell injury. Unlike previous reports, some researchers indicated that ethyl alcohol pretreatment can improve renal antioxidant activities and capacity.

  • Abstinence is one of the characteristics of human drinking habits; many doctors will encourage patients to stop drinking, which may be good for their health [121].
  • See your doctor to treat kidney stones or a kidney infection if they are the cause.
  • Nowadays, many forms of ethyl alcohol are available, such as beer, wine, vodka, and other spirits, and these have become very popular among adults.
  • The more alcohol consumed the higher the risk of elevated blood pressure.

Moreover, alcohol-induced renal tubular dysfunction is also reflected in vitamin reabsorption disorders. Subramanian et al. proved that chronic alcohol consumption can significantly inhibit carrier-mediated thiamin and biotin transport across the renal brush border membrane and basolateral membrane [54,55]. Although hepatorenal syndrome often ensues after an event that reduces blood volume (e.g., gastrointestinal bleeding), it also can occur without any apparent precipitating factor. Some observers have noted that patients with cirrhosis frequently develop hepatorenal syndrome following hospital admission, possibly indicating that a hospital-related event can trigger the syndrome. Regardless of the precipitating factor, patients who develop kidney failure in the course of alcoholic cirrhosis have a grave prognosis.

Causes of kidney pain after alcohol

To make sure the medicine does its job, it’s a good idea to cut back on alcohol or skip it altogether. Jen Hernandez is a registered dietitian and board-certified specialist in renal nutrition. She has nearly a decade of experience with kidney disease patients in all stages – from stage 1 through kidney transplant. Jen writes on the blog of Plant-Powered Kidneys to help reach and teach more kidney patients about how they can enjoy more foods in a plant-based diet while protecting kidney health. On the other hand, a 2015 article showed moderate drinking somewhat reduced the risk of kidney stones forming.

alcohol and kidneys

Alcohol may also indirectly increase your risk of developing a UTI, which can cause kidney or abdominal pain. If you’re currently taking medications for kidney cancer or are having surgery to remove a kidney (nephrectomy), talk with your doctor about how much alcohol is safe to have during treatment. Over time, alcohol can damage the kidneys, according to the National Kidney Foundation. So, if you drink alcohol, especially often, the kidneys must work harder to return your blood to its usual state. If you are living with diabetes and kidney disease, it is important to stay in control of your blood sugar so you can be your healthiest and avoid other…

Options abound when it comes to eating vegetarian while living with kidney disease

Binge drinking causes a person’s blood alcohol content to rise to dangerous levels, which in turn causes the kidneys to lose their function so much, the term for this is acute kidney injury. In general, excessive alcohol consumption leads to liver damage [29]. However, some studies have found that ethanol can directly cause kidney damage, independent of liver damage [28,30,31]. Latchoumycandane et does alcohol affect your kidneys al. found that the effects of excessive ethanol metabolism alone are sufficient to significantly damage kidney function, without heavy liver dysfunction. Moreover, ethanol-induced kidney injury correlates with leukocyte infiltration and activation without oxidative ethanol catabolism by CYP2E1 [28]. Even without binge drinking, regularly drinking too much too often can also damage the kidneys.

alcohol and kidneys

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Due to the development of alcoholic cardiomyopathy, chronic renal hypoxia develops, activating the renin–angiotensin–aldosterone system (RAAS), which in turn leads to further free radical production and to the propagation of fibrotic pathways. In contrast, some studies find that heavy alcohol consumption may predict poorer outcome in patients with chronic kidney diseases (Kronborg et al. 2008; Shankar et al. 2006; White et al. 2009). For example, White and colleagues (2009) reported that heavier drinkers (those consuming more than 30 g of alcohol/week) were at higher risk of incident albuminuria, which is typically a symptom of kidney disease. Japanese (Yamagata et al. 2007) and Italian (Buja et al. 2011) cohort studies revealed a U-shaped association between alcohol consumption and incidence of proteinuria.